A study by the Balearic Islands Health Research Institute (IDISBA) revealed hidden mutations in little-explored areas of human DNA, known as 'dark DNA,' that could drive the progression of aggressive brain tumors. A discovery that opens the door to better diagnosis of the disease. The international team led by Dr. Diego Marzese has discovered genetic changes in little-explored areas of human DNA that could help explain why glioblastoma, the most aggressive brain tumor, is so difficult to treat, the Regional Ministry of Health explained in a statement.